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Trans-Dermal Delivery

03 Nov 2021
Collagen Trans-Dermal Delivery

Upon transdermal application and skin absorption, COLWAY Marine Collagen spirals break down and EMC is immediately enriched by the supply in abundance of key amino acids, glycine, proline and hydroxyproline, and other active ingredients that activate the function in the skin of fibroblasts and keratinocytes. Consequently, pro-collagen formed in the fibroblasts is synthesized into helices.

COLWAY Marine Collagen’s triple helix structure has a triple boosting effect on skin’s own collagen synthesis:

  • Awakens fibroblasts and stimulates protein production
  • Protects collagen from degradation and destruction
  • Helps maintain collagen quantity and quality

When the COLWAY Marine Collagen is applied to the skin immediately after the face is cleansed while the pores are open for maximum assimilation of the collagen into the lower layers of the skin, it enriches the ECM of all the layers of the skin with amino acids, which facilitates fibroblast activity. At the same time, it increases the organism’s production of its own collagen.

Once applied on the skin, the enzyme collagenase breaks down collagen’s molecular structure. As a result the denaturation temperature (temperature above or below the range in which cells tend to live that will cause proteins to unfold or “denature”) for the triple helix structure decreases, allowing it to unravel at body temperature, and then enzymes such as elastase and gelatinase break down the unraveled helix into lower molecular weight compounds (extracellular route). At the same time, another route is used, in which collagen is taken into cells like macrophages (defense cells) and broken down in those cells.

Because collagen from other sources and other processes melts at a much higher temperature, it often sits on the skin without melting or being absorbed. The processing of COLWAY Marine Collagen allows for a lower molecular weight and lower denaturation rate which enables its molecular structure to easily melt on the skin and be gradually absorbed.

For the extracellular space (everything outside a cells, excluding ECM), the ECM is a collagen ‘factory’ of fibroblasts, chondrocytes and keratinocytes freeing the polypeptide amino acid chains. It is here, with the help of ascorbic acid (Vitamin C) as an activator, the amino acid sequence twists into helices. The ECM is reinforced when it is infused with peptides which are absorbed and dissolved on their way through the high capacity layers of the marine collagen spirals - ultimately increasing the amount of collagen in the ECM.

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